Product Name: ERK3 (186-192) pS189
Product Number: PE-04AKF90
| Size: | 200 µg | Price: | 37.00 | |
| 1 mg | $US | 74.00 | ||
| 5 mg | 174.00 |
Peptide Name: ERK3 (186-192) pS189
Product Use: Services as a blocking peptide for use with the ERK3-pS189 rabbit polyclonal antibody (Cat. No.: AB-PK623) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. S189 phosphorylation stimulates phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: GHL-pS-EGL
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the ERK3-pS189 rabbit polyclonal antibody (Cat. No.: AB-PK623) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. S189 phosphorylation stimulates phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: GHL-pS-EGL
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 965.95 Da
Peptide Purity Percent after Synthesis and Purification: >90
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: ERK3 - pS189 phosphosite-specific antibody (Cat. No.: AB-PK623)
Peptide Molecular Mass Calculated: 965.95 Da
Peptide Purity Percent after Synthesis and Purification: >90
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: ERK3 - pS189 phosphosite-specific antibody (Cat. No.: AB-PK623)
Scientific Background: ERK3 (MAPK6) is a protein-serine/threonine kinase of the CMGC group and MAPK family. ERK3 is highly expressed in the skeletal muscle and the brain. It is located in nucleus and has been shown to be activating in fibroblasts with serum or phorbol esters treatments. Phosphorylation at S189 increases its phosphotransferase activity. Overexpression of ERK3 in fibroblasts inhibits S-phase entry. It may act as a negative regulator of cell proliferation. It is downregulated in different tumour types. However regulation and function of ERK3 remains to be fully elucidated. It phosphorylates MAP2.
© Kinexus Bioinformatics Corporation 2017