Product Name: ROCK2 (719-725) pY722
Product Number: PE-04ALB99
| Size: | 200 µg | Price: | 47.00 | |
| 1 mg | $US | 94.00 | ||
| 5 mg | 206.00 |
Peptide Name: ROCK2 (719-725) pY722
Product Use: Services as a blocking peptide for use with the ROCK2-pY722 rabbit polyclonal antibody (Cat. No.: AB-PK799) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the region between the kinase catalytic and Rho_Binding domains. The major site of phosphorylation in ROCK2. Phosphorylation inhibits phosphotransferase activity and inhibits interaction with RhoA.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: NKI-pY-ESI
Peptide Modifications N Terminus: Free amino
Product Use: Services as a blocking peptide for use with the ROCK2-pY722 rabbit polyclonal antibody (Cat. No.: AB-PK799) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the region between the kinase catalytic and Rho_Binding domains. The major site of phosphorylation in ROCK2. Phosphorylation inhibits phosphotransferase activity and inhibits interaction with RhoA.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: NKI-pY-ESI
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1120.15 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: ROCK2 - pY722 phosphosite-specific antibody (Cat. No.: AB-PK799)
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1120.15 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: ROCK2 - pY722 phosphosite-specific antibody (Cat. No.: AB-PK799)
Scientific Background: ROCK2 (ROK-alpha) is a protein-serine/threonine kinase of the AGC group and DMPK family. It regulates the actin cytoskeleton and cell polarity,and is involved in the regulation of smooth muscle contraction, formation of stress fibre and focal adhesions, cell adhesion, and cell motility. It is activated by binding to the small G protein RhoA, and by phosphorylation at T967 and S1099. It is inhibited by phosphorylation at Y722. Insertional mutagenesis studies in mice support a role for this protein kinase in mouse cancer oncogenesis.
© Kinexus Bioinformatics Corporation 2017