Product Name: TIE2 (989-995) pY992
Product Number: PE-04ALI90
| Size: | 200 µg | Price: | 41.00 | |
| 1 mg | $US | 82.00 | ||
| 5 mg | 194.00 |
Peptide Name: TIE2 (989-995) pY992
Product Use: Services as a blocking peptide for use with the TIE2-pY992 rabbit polyclonal antibody (Cat. No.: AB-PK831) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y992 phosphorylation stimulates phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: QEV-pY-VKK
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the TIE2-pY992 rabbit polyclonal antibody (Cat. No.: AB-PK831) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y992 phosphorylation stimulates phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: QEV-pY-VKK
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1147.21 Da
Peptide Purity Percent after Synthesis and Purification: >90
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: TIE2 - pY992 phosphosite-specific antibody (Cat. No.: AB-PK831)
Peptide Molecular Mass Calculated: 1147.21 Da
Peptide Purity Percent after Synthesis and Purification: >90
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: TIE2 - pY992 phosphosite-specific antibody (Cat. No.: AB-PK831)
Scientific Background: TIE2 (TEK) is a receptor protein-tyrosine kinase of the TK group and Tie family. It functions as a membrane receptor for ANGPT1, ANGPT2, and ANGPT4 and is involved in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion, actin cytoskeleton dynamics, and vascular quiescence. TIE2 expression is required for the normal development of the heart and blood vessels and for hematopoiesis post-natally. After birth, TIE2 expression can either promote or inhibit angiogenesis dependent upon the cellular context. In addition, TIE2 also has anti-inflammatory activity by preventing pro-inflammatory plasma proteins and leukocytes from leaking through the blood vessel endothelium. TIE2 directly phosphorylates DOK2, GRB7, GRB14, PIK3R1, Shc1, and TIE1 to mediate its effects. In mice, rats, and humans, TIE2 expression is almost exclusively in endothelial cells that line the vasculature. TIE2 has been demonstrated to be essential for the maintenance of hematopoeitic stem cells (HSCs) in a quiescent state in the bone marrow, which is required for the ongoing process of hematopoeisis. Phosphorylation at Y897 inhibits TIE2 phosphotransferase activity.
© Kinexus Bioinformatics Corporation 2017