Product Name: Fer (711-717) pY714
Product Number: PE-04AMF99
| Size: | 200 µg | Price: | 47.00 | |
| 1 mg | $US | 94.00 | ||
| 5 mg | 206.00 |
Peptide Name: Fer (711-717) pY714
Product Use: Services as a blocking peptide for use with the FER-pY714 rabbit polyclonal antibody (Cat. No.: AB-PK631) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y714 phosphorylation stimulates phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: GGV-pY-SSS
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the FER-pY714 rabbit polyclonal antibody (Cat. No.: AB-PK631) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y714 phosphorylation stimulates phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: GGV-pY-SSS
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 908.9 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Fer - pY714 phosphosite-specific antibody (Cat. No.: AB-PK631)
Peptide Molecular Mass Calculated: 908.9 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Fer - pY714 phosphosite-specific antibody (Cat. No.: AB-PK631)
Scientific Background: Fer is a protein-tyrosine kinase of the TK group and Fer family. Fer is a downstream mediator of growth factor signalling through EGF and PDGF receptor tyrosine kinases. It regulates cell adhesion and mediates signalling downstream of growth factor receptors. It has a role in regulating actin cytoskeleton and microtubule assembly required for cellular migration and attachment. It has a wide range of functions including potential regulation of the mitotic cell cycle, regulation of mast cell degranulation, leukocyte recruitment, and neuronal cell death after brain damage. Changes in leukocyte migration in Fer mutant mice indicate Fer may have a role in innate immunity regulation. This kinase is moderate to highly expressed in most tested human tissues. Fer has been found to activate NF-kB and promote cell proliferation. Overexpression of Fer has been implicated in increasing the tumorigenicity of prostate cancer cell lines as well as increasing resistance to chemotherapeutics such as quinacrine which inhibits NF-kB activation. Fer is highly related in structure to Fes/Fps, which is an oncoprotein that was originally identified in chicken and cat retroviral-induced cancers. Fer is required for cell-cycle progression in malignant cells. Decreasing the level of Fer using RNAi impeded the proliferation of prostate and breast carcinoma cells and led to their arrest at the G0/G1 phase. Fer has also been linked with the development of lung small cell carcinomas (LSCC).
© Kinexus Bioinformatics Corporation 2017