Product Name: Fgr (205-212) pY208+pY209
Product Number: PE-04AMH80
| Size: | 200 µg | Price: | 17.00 | |
| 1 mg | $US | 33.00 | ||
| 5 mg | 91.00 |
Peptide Name: Fgr (205-212) pY208+pY209
Product Use: Services as a blocking peptide for use with the FGR-pY208+pY209 rabbit polyclonal antibody (Cat. No.: AB-PK638) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the SH2 domain. This is the major in vivo phosphorylation sites in Fgr. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: MGG-pY-pY-ITT
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the FGR-pY208+pY209 rabbit polyclonal antibody (Cat. No.: AB-PK638) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the SH2 domain. This is the major in vivo phosphorylation sites in Fgr. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: MGG-pY-pY-ITT
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1239.18 Da
Peptide Purity Percent after Synthesis and Purification: >50
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Fgr - pY208+pY209 phosphosite-specific antibody (Cat. No.: AB-PK638)
Peptide Molecular Mass Calculated: 1239.18 Da
Peptide Purity Percent after Synthesis and Purification: >50
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Fgr - pY208+pY209 phosphosite-specific antibody (Cat. No.: AB-PK638)
Scientific Background: Fgr is a protein-tyrosine kinase of the TK group and Src family. It is a non-receptor kinase that transmits signals from cell surface receptors and regulates immune responses. In addition, it functions as positive regulator of cell migration and regulates cytoskeleton reorganization. Fgr appears to be an oncoprotein (OP). A Y523F mutation in Fgr is associated with strongly increased catalytic activity, which can be oncogenic and promote abnormal cell proliferation. Fgr oncogene mRNA was found to be induced in B lymphocytes by Epstein-Barr virus infection.
© Kinexus Bioinformatics Corporation 2017