Product Name: IKKa (178-184) pT179+pS180
Product Number: PE-04AMV99
| Size: | 200 µg | Price: | 58.00 | |
| 1 mg | $US | 115.00 |
Peptide Name: IKKa (178-184) pT179+pS180
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. T179 and S180 phosphorylation stimulate phosphotransferase activity and regulates chromatin organization, transcription, molecular association and ubiquitination.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CC-pT-pS-FVGT
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. T179 and S180 phosphorylation stimulate phosphotransferase activity and regulates chromatin organization, transcription, molecular association and ubiquitination.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CC-pT-pS-FVGT
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1046.98 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Molecular Mass Calculated: 1046.98 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Scientific Background: IKKa (IKBKA, CHUK)) is a protein-serine/threonine kinase of the Other group and IKK family. It is involved in NF-kappa-B pathway, which activates multiple stress stimuli including inflammatory cytokines, infection, and DNA damage. The activity of the kinase enables for NF-kappa-B to enter the nucleus and stimulate the transcription of genes involved in the immune response, control of cell growth, and cellular protection against apoptosis. It is Inhibited by phosphorylation at S733, S740, and S750.
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