Product Name: MERTK (746-752) pY749
Product Number: PE-04ANY99
Size: | 200 µg | | Price: | 47.00 |
| 1 mg | | $US | 94.00 |
| 5 mg | | | 206.00 |
Peptide Name: MERTK (746-752) pY749
Product Use: Services as a blocking peptide for use with the MERTK-pY749 rabbit polyclonal antibody (Cat. No.: AB-PK702) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y749 phosphorylation stimulates phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: KKI-pY-SGD
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Scientific Background: MERTK (Mer) is a protein-tyrosine kinase of the TK group and Axl family. It is a receptor kinase that functions in the regulation of cell survival, angiogenesis, migration and invasion, differentiation, and phagocytosis of apoptotic cells. Phosphorylation of Y749, Y753 and Y754 increases phosphotransferase activity.