Product Name: PKD2 (194-201) pS197+pS198
Product Number: PE-04APB99
| Size: | 200 µg | Price: | 65.00 | |
| 1 mg | $US | 129.00 | ||
| 5 mg | 283.00 |
Peptide Name: PKD2 (194-201) pS197+pS198
Product Use: Services as a blocking peptide for use with the PRKD2-pS197+pS198 rabbit polyclonal antibody (Cat. No.: AB-PK784) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the C1_1 domain. The effect of its phosphorylation is unclear. These are the major in vivo sites of phosphorylation of PRKD2.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: RRL-pS-pS-TSL
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the PRKD2-pS197+pS198 rabbit polyclonal antibody (Cat. No.: AB-PK784) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the C1_1 domain. The effect of its phosphorylation is unclear. These are the major in vivo sites of phosphorylation of PRKD2.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: RRL-pS-pS-TSL
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1252.2 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: PKD2 - pS197+pS198 phosphosite-specific antibody (Cat. No.: AB-PK784)
Peptide Molecular Mass Calculated: 1252.2 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: PKD2 - pS197+pS198 phosphosite-specific antibody (Cat. No.: AB-PK784)
Scientific Background: PRKD2 (PKD2) is a protein-serine/threonine kinase of the CAMK group and PKD family. It lengthens the signal induced by diacylglycerol (DAG) by modulating the cascade downstream from PKC. It is activated by DAG and phorbol esters. Phorbol-ester/DAG-type domains bind DAG, mediating PRKD2 translocation to membranes. Autophosphorylation of S710 and phosphorylation of S706 by PKC relieves auto-inhibition by the PH domain PRKD2 can mediate NF-kB activation (induced from oxidative stress), cell proliferation (induced from MAPK1/3 signalling), inhibition of the transcription repression for HDAC7, T-cell antigen receptor signalling cascade, golgi apparatus vesicle trafficking, cell adhesion, angiogenesis, and secretory granule release.
© Kinexus Bioinformatics Corporation 2017