Product Name: SRPK1 (219-225) pS222
Product Number: PE-04APR99
| Size: | 200 µg | Price: | 42.00 | |
| 1 mg | $US | 84.00 | ||
| 5 mg | 185.00 |
Peptide Name: SRPK1 (219-225) pS222
Product Use: Services as a blocking peptide for use with the SRPK1-pS222 rabbit polyclonal antibody (Cat. No.: AB-PK819) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located near the N-terminus of the kinase. S222 phosphorylation stimulates phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: ILG-pS-DDD
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the SRPK1-pS222 rabbit polyclonal antibody (Cat. No.: AB-PK819) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located near the N-terminus of the kinase. S222 phosphorylation stimulates phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: ILG-pS-DDD
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 986.91 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: SRPK1 - pS222 phosphosite-specific antibody (Cat. No.: AB-PK819)
Peptide Molecular Mass Calculated: 986.91 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: SRPK1 - pS222 phosphosite-specific antibody (Cat. No.: AB-PK819)
Scientific Background: SRPK1 (SFRSK1) is one of several protein kinases that can phosphorylate KinSub5RRLSP. It is a protein-serine/threonine kinase of the CMGC group and SRPK family. This kinase is moderate to highly expressed in most tested human tissues except apparently in the brain and spinal cord. SRPK1 is activated by phosphorylation at S51 and S555. In human cancer cells, it was observed that inactivation of SRPK1 induces cellular resistance to anticancer drugs such as cisplatin and bleomycin. SRPK1 phosphorylates serine/arginine-rich (SR) proteins, such as splicing factors ASF/SF2, SC35, and SRp55, in their arginine/serine-rich (RS) domains in vitro. Consequently, it is believed that SRPK1 plays a key role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors.
© Kinexus Bioinformatics Corporation 2017