Product Name: SRPK2 (316-322) pY319
Product Number: PE-04APS90
| Size: | 200 µg | Price: | 41.00 | |
| 1 mg | $US | 82.00 | ||
| 5 mg | 194.00 |
Peptide Name: SRPK2 (316-322) pY319
Product Use: Services as a blocking peptide for use with the SRPK2-pY319 rabbit polyclonal antibody (Cat. No.: AB-PK820) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the insert region between the kinase catalytic domain. This is the major in vivo phosphorylation site in SRPK2. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: DGE-pY-CPE
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the SRPK2-pY319 rabbit polyclonal antibody (Cat. No.: AB-PK820) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the insert region between the kinase catalytic domain. This is the major in vivo phosphorylation site in SRPK2. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: DGE-pY-CPE
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1065 Da
Peptide Purity Percent after Synthesis and Purification: >90
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: SRPK2 - pY319 phosphosite-specific antibody (Cat. No.: AB-PK820)
Peptide Molecular Mass Calculated: 1065 Da
Peptide Purity Percent after Synthesis and Purification: >90
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: SRPK2 - pY319 phosphosite-specific antibody (Cat. No.: AB-PK820)
Scientific Background: SRPK2 (SFRSK2) is a protein-serine/threonine kinase of the CMGC group and SRPK family. This kinase is moderate to highly expressed in most tested human tissues. It is a member of the serine/arginine (SR) protein-specific kinase family that are cell cycle-regulated protein kinases which phosphorylate SR domain-containing proteins in nuclear speckles and mediate the pre-mRNA splicing events. It phosphorylates SFRS1 and SFRS2 on serine residues. It is involved in spliceosome assembly and splicing factor trafficking. SRPK2 is activated by phosphorylation at S52 and S588. SRPK2 knock down results in hypophosphorylation of the serine/arginine domain-containing human PRP28 protein thereby destabilizing PRP28 association with the tri-snRNP. RNAi-mediated depletion in HeLa cells showed that SRPK2 is essential for cell viability, and it is required for spliceosomal B complex formation. SRPK2 has been linked with the development of glioblastoma multiforme (GM).
© Kinexus Bioinformatics Corporation 2017