Product Name: TIF1b (514-520) pY517
Product Number: PE-04APY99
Size: 200 µg      Price:47.00
1 mg      $US94.00
5 mg      206.00
Peptide Name: TIF1b (514-520) pY517

Product Use: Services as a blocking peptide for use with the TRIM28-pY517 rabbit polyclonal antibody (Cat. No.: AB-PK835) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the region between the zf-B_box and PHD domains. The major site of phosphorylation in TRIM28. Y517 phosphorylation stimulates interaction with HP1 alpha and induces DNA repair.

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Homo sapiens

Peptide Sequence: TED-pY-NLI

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: βAla-Cys

Peptide Modifications Other: Phosphorylated

Peptide Molecular Mass Calculated: 1120.1 Da

Peptide Purity Percent after Synthesis and Purification: >95

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Related Product 1: TIF1b - pY517 phosphosite-specific antibody (Cat. No.: AB-PK835)

Scientific Background: TRIM28 (TIF1b)) is a protein-serine/threonine kinase of the Atypical group and TIF1 family. TIF family members are associated in retroviral restriction. TRIM28 contributes to EMT via E-cadherin and N-cadherin regulation in lung cancer cell lines.