Product Name: TIF1b (470-476) pS473
Product Number: PE-04AQA01
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Peptide Name: TIF1b (470-476) pS473
Product Use: Services as a blocking peptide for use with the TRIM28-pS473 rabbit polyclonal antibody (Cat. No.: AB-PK833) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the mid-region of the protein kinase between the zf-B_box and PHD domains. S473 phosphorylation stimulates transcription and induces DNA repair and inhibits interaction with HP1-alpha.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: RSR-pS-GEG
Peptide Modifications N Terminus: Free amino
Product Use: Services as a blocking peptide for use with the TRIM28-pS473 rabbit polyclonal antibody (Cat. No.: AB-PK833) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the mid-region of the protein kinase between the zf-B_box and PHD domains. S473 phosphorylation stimulates transcription and induces DNA repair and inhibits interaction with HP1-alpha.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: RSR-pS-GEG
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1000.97 Da
Storage Conditions: -20°C
Related Product 1: TIF1b - pS473 phosphosite-specific antibody (Cat. No.: AB-PK833)
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1000.97 Da
Storage Conditions: -20°C
Related Product 1: TIF1b - pS473 phosphosite-specific antibody (Cat. No.: AB-PK833)
Scientific Background: TRIM28 (TIF1b)) is a protein-serine/threonine kinase of the Atypical group and TIF1 family. TIF family members are associated in retroviral restriction. TRIM28 contributes to EMT via E-cadherin and N-cadherin regulation in lung cancer cell lines.
© Kinexus Bioinformatics Corporation 2017