Product Name: Tyro3 (682-689) pY685+pY686
Product Number: PE-04AQL90
| Size: | 200 µg | Price: | 56.00 | |
| 1 mg | $US | 111.00 | ||
| 5 mg | 241.00 |
Peptide Name: Tyro3 (682-689) pY685+pY686
Product Use: Services as a blocking peptide for use with the Tyro3-pY685+pY686 rabbit polyclonal antibody (Cat. No.: AB-PK848) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. Y685 and Y686 phosphorylation is predicted to be stimulatory for phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: SGD-pY-pY-RQG
Peptide Modifications N Terminus: Free amino
Product Use: Services as a blocking peptide for use with the Tyro3-pY685+pY686 rabbit polyclonal antibody (Cat. No.: AB-PK848) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. Y685 and Y686 phosphorylation is predicted to be stimulatory for phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: SGD-pY-pY-RQG
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1278.1 Da
Peptide Purity Percent after Synthesis and Purification: >80
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Tyro3 - pY685+pY686 phosphosite-specific antibody (Cat. No.: AB-PK848)
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1278.1 Da
Peptide Purity Percent after Synthesis and Purification: >80
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Tyro3 - pY685+pY686 phosphosite-specific antibody (Cat. No.: AB-PK848)
Scientific Background: Tyro3 is a receptor protein-tyrosine kinase of the TK group and Axl family. It responds to TUB, TULP1, GAS6 and protein S as ligands and regulates cell survival, proliferation, immunoregulation, phagocytosis, cell migration, actin organization, spermatogenesis, platelet aggregation, clot stabilization, memory formation, circadian rhythm and synaptic plasticity. This kinase is moderate to highly expressed in most tested human tissues; it is expressed in the brain (where it is involved in the protection of neurons from apoptosis), expressed in lymphoid, vascular and reproductive tissue and in primary and tumour cell lines. Tyro3 interacts with GAS6. Tyro3 together with AXL and MER form the AXL/Tyro3 family of receptor-tyrosine kinases. Members of this family play an essential role in spermatogenesis, immunoregulation, and phagocytosis. In addition to signal transduction, Tyro3 participates in cell adhesion. Gas6, a product of growth arrest-specific gene, activates the kinase activity of all three receptors. Signalling transduction can occur via MAPK/ERK and Pi3K/Akt pathways. Overexpression in various cancers provide transformative ability and increased survival signals. Tyro3 has been linked with the development of mammary cancer and multiple myelomas. Tyro3 may also be a potential therapeutic target in breast cancer.
© Kinexus Bioinformatics Corporation 2017