Product Name: Pyk2 (399-405) pY402
Product Number: PE-04AQQ99
| Size: | 200 µg | Price: | 47.00 | |
| 1 mg | $US | 94.00 | ||
| 5 mg | 206.00 |
Peptide Name: Pyk2 (399-405) pY402
Product Use: Services as a blocking peptide for use with the PYK2-pY402 rabbit polyclonal antibody (Cat. No.: AB-PK788) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the region between the FERM_M domain and the protein kinase catalytic domain. Y402 phosphorylation stimulates phosphotransferase activity. Phosphorylation regulates cell cycle progression, cell motility, alters intracellular location, and induces binding to ErbB2, RASA1 and Src.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: SDI-pY-AEI
Peptide Modifications N Terminus: Free amino
Product Use: Services as a blocking peptide for use with the PYK2-pY402 rabbit polyclonal antibody (Cat. No.: AB-PK788) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the region between the FERM_M domain and the protein kinase catalytic domain. Y402 phosphorylation stimulates phosphotransferase activity. Phosphorylation regulates cell cycle progression, cell motility, alters intracellular location, and induces binding to ErbB2, RASA1 and Src.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: SDI-pY-AEI
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1063.06 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Pyk2 - pY402 phosphosite-specific antibody (Cat. No.: AB-PK788)
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1063.06 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Pyk2 - pY402 phosphosite-specific antibody (Cat. No.: AB-PK788)
Scientific Background: Pyk2 (PTK2B, FAK2) is a protein-tyrosine kinase of the TK group and Fak family. It is a non-receptor kinase that has a role in actin cytoskeleton rearrangement, cell migration, cell polarization, adhesion, bone remodeling, and controlling amount of marginal B-cells' migration and presence in the spleen. Phosphorylation at TY402 increases phosphotransferase activity and induces interaction with ErbB2, RasGAP and Src. Phosphorylation at Y579 increases its phosphotransferase activity. NPHP1 interaction with Pyk2 has been interrupted with a P859A mutation. A phosphorylation site of Pyk2 can be inhibited with an Y881F mutation, which will also impair GRB2 interaction.
© Kinexus Bioinformatics Corporation 2017