Product Name: MBP (228-235) pT232
Product Number: PE-04AQS99
| Size: | 200 µg | Price: | 45.00 | |
| 1 mg | $US | 91.00 | ||
| 5 mg | 199.00 |
Peptide Name: MBP (228-235) pT232
Product Use: Services as a blocking peptide for use with the MBP-pT232 rabbit polyclonal antibody (Cat. No.: AB-PN558) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the middle of the Myelin_MBP domain in the C-terminal half of the protein. This is the main phosphosite targeted by the ERK1 and ERK2 MAP kinases. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: VTPR-pT-PPP
Peptide Modifications N Terminus: Free amino
Product Use: Services as a blocking peptide for use with the MBP-pT232 rabbit polyclonal antibody (Cat. No.: AB-PN558) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the middle of the Myelin_MBP domain in the C-terminal half of the protein. This is the main phosphosite targeted by the ERK1 and ERK2 MAP kinases. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: VTPR-pT-PPP
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1117.18 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: MBP - pT232 phosphosite-specific antibody (Cat. No.: AB-PN558)
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1117.18 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: MBP - pT232 phosphosite-specific antibody (Cat. No.: AB-PN558)
Scientific Background: Myelin basic protein (MBP) isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They are involved in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. Non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) appear to have a role in the early developing brain long before myelination, possibily as components of transcriptional complexes, and may also be involved in signalling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
© Kinexus Bioinformatics Corporation 2017