Product Name: ATF2 (66-74) pT69+pT71
Product Number: PE-04ARD99
| Size: | 200 µg | Price: | 68.00 | |
| 1 mg | $US | 136.00 | ||
| 5 mg | 297.00 |
Peptide Name: ATF2 (66-74) pT69+pT71
Product Use: Services as a blocking peptide for use with the ATF2-pT69 + pT71 rabbit polyclonal antibody (Cat. No.: AB-PN552) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the N-terminus of the transcription factor. These are the major in vivo sites of phosphorylation of ATF2. Phosphorylation increases transcriptional activity
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: ADQ-pT-P-pT-PTR
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the ATF2-pT69 + pT71 rabbit polyclonal antibody (Cat. No.: AB-PN552) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the N-terminus of the transcription factor. These are the major in vivo sites of phosphorylation of ATF2. Phosphorylation increases transcriptional activity
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: ADQ-pT-P-pT-PTR
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1319.2 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: ATF2 - pT69+pT71 phosphosite-specific antibody (Cat. No.: AB-PN552)
Peptide Molecular Mass Calculated: 1319.2 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: ATF2 - pT69+pT71 phosphosite-specific antibody (Cat. No.: AB-PN552)
Scientific Background: ATF2 is a transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. In combination with its binding partner, ATF2 binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, it contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. It exhibits histone acetyltransferase (HAT) activity that specifically acetylates histones H2B and H4. In concert with CUL3 and RBX1, it promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM.
© Kinexus Bioinformatics Corporation 2017