Product Name: CDK10 (193-207) pT196+pT201+pY204
Product Number: PE-04ASI90
Size: 200 µg      Price:81.00
1 mg      $US162.00
5 mg      350.00
Peptide Name: CDK10 (193-207) pT196+pT201+pY204

Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. T196 phosphorylation is stimulatory, and T201 and Y204 phosphorylation are predicted to be inhibitory.

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Homo sapiens

Peptide Sequence: KPM-pT-PKVV-pT-LW-pY-RAP

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: βAla-Cys

Peptide Modifications Other: Phosphorylated

Peptide Molecular Mass Calculated: 2200.3 Da

Peptide Purity Percent after Synthesis and Purification: >80

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Storage Stability: stable as powder

Scientific Background: CDK10 (PISSLRE) is a protein-serine/threonine kinase of the CMGC group and CDK family. It is a protein kinase that mediates phosphorylation and degradation of ETS2 (a transcription factor). CDK10 appears to be a tumour requiring protein (TRP). It displays one of the lowest rates of mutation in human tumours. The near absence of reported somatic mutations in this protein indicates that it may function as a tumour requiring protein (TRP) in many human tumours.