Product Name: CDKL5 (172-180) pT174+pY177
Product Number: PE-04ASU01
Size: 200 µg      Price:15.00
1 mg      $US30.00
Peptide Name: CDKL5 (172-180) pT174+pY177

Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. T174 and Y177 phosphorylation is predicted to be inhibitory to phosphotransferase activity.

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Homo sapiens

Peptide Sequence: VA-pT-RW-pY-RSP

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: Amide

Peptide Modifications Other: Phosphorylated
Peptide Purity Percent after Synthesis and Purification: >50

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Storage Stability: stable

Scientific Background: CDKL5 is a protein-serine/threonine kinase of the CMGC group and CDKL family. It is likely that phosphorylation at Y24 is inhibitory and phosphorylation at Y171 is required for catalytic activity based on homology with other CDK's. It has been reported to phosphorylate MECP2. Insertional mutagenesis studies in mice support a role for this protein kinase in mouse cancer oncogenesis. It has also been linked with Rett Syndrome, which is a neuro-development disorder affecting psychomotor development, autistic like features, seizures, and slow head growth. Rett Syndrome is also associated with neuroblastomas.