Product Name: DAPK3 (176-184) pT180
Product Number: PE-04ASX95
Size: 200 µg      Price:11.00
1 mg      $US22.00
5 mg      60.00
Peptide Name: DAPK3 (176-184) pT180

Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. T180 phosphorylation is predicted to be inhibitory for phosphotransferase activity.

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Homo sapiens

Peptide Sequence: NIFG-pT-PEFV

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: βAla-Cys

Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1276.3 Da

Peptide Purity Percent after Synthesis and Purification: ~50

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Storage Stability: Not stable

Scientific Background: DAPK3 (also known as ZIP) is a protein-serine/threonine kinase that is a member of the CAMK group of protein kinases in the DAPK family. This kinase is moderate to highly expressed in most tested human tissues. Orthologues of DAPK3 are highly conserved in animals and plants. DAPK3 is activated by phosphorylation at T180, T225, and T265. Homodimers of DAPK3 or heterodimers with ATF4 formed via a leucine zipper domain is required for full enzymatic activity. DAPK3 plays a role in apoptosis. It phosphorylates core histones H3 and H4, and myosin light chain in vitro. DAPK3 interacts with transcription and splicing factors as well as with pro-apoptotic protein Par-4.