Product Name: ICK (158-164) pY159+pS161+pT162
Product Number: PE-04AVB01
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Peptide Name: ICK (158-164) pY159+pS161+pT162
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. Y159 phosphorylation stimulates phosphotransferase activity. S161 and T162 phosphorylations are predicted to inhibit phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: D(pY)V(pS)(pT)RW
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. Y159 phosphorylation stimulates phosphotransferase activity. S161 and T162 phosphorylations are predicted to inhibit phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: D(pY)V(pS)(pT)RW
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Modifications Other: Phosphorylated
Storage Conditions: -20°C
Storage Conditions: -20°C
Scientific Background: ICK is a protein-serine/threonine kinase of the CMGC group and RCK family. It displays sequence similarity to the MAP kinases in the catalytic domain and the requirement for dual phosphorylation for activation within a MAP kinase-like TDY motif. ICK functions in the regulation of proliferation and differentiation in intestinal cells. Impairing ICK function has been shown to dowregulate the translation of specific targets of eIF4E and S6K1 (e.g. cyclin D1 and c-Myc) mediated through the mTOR/Raptor signalling pathway. Additionally, ICK homologuess in algae and invertebrates function in the formation of flagella and in ciliogenesis.
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