Product Name: KHS1 (165-177) pT168 +pS174
Product Number: PE-04AVS95
| Size: | 200 µg | Price: | 40.00 | |
| 1 mg | $US | 81.00 |
Peptide Name: KHS1 (165-177) pT168 +pS174
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The presentation as a dimer increases the potential activity. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. T168 phosphorylation is predicted to be stimulatory for phosphotransferase activity. S174 phosphorylation is stimulatory for phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: (ITA-pT-IAKRK-pS-FIG-βA-Cys)2
Peptide Modifications N Terminus: Free amino
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The presentation as a dimer increases the potential activity. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. T168 phosphorylation is predicted to be stimulatory for phosphotransferase activity. S174 phosphorylation is stimulatory for phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: (ITA-pT-IAKRK-pS-FIG-βA-Cys)2
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Modifications Other: Phosphorylated, dimer
Peptide Molecular Mass Calculated: 3560.2 Da
Peptide Purity Percent after Synthesis and Purification: >50
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Storage Stability: Stable as dimer
Peptide Modifications Other: Phosphorylated, dimer
Peptide Molecular Mass Calculated: 3560.2 Da
Peptide Purity Percent after Synthesis and Purification: >50
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Storage Stability: Stable as dimer
Scientific Background: KHS1 (MAP4K5) is a protein-serine/threonine kinase of the STE group and STE20 family. It has been proposed to be upstream of the JUN N-terminal pathway and may respond to environmental stresses. A mutation in KHS1, K49R, inhibits the kinase phosphotransferase activity and inhibits downstream JNK proteins.
© Kinexus Bioinformatics Corporation 2017