Product Name: MOK (156-170) pT159+pY161+pT164+pY167
Product Number: PE-04AWM75
| Size: | 200 µg | Price: | 29.00 | |
| 1 mg | $US | 58.00 |
Peptide Name: MOK (156-170) pT159+pY161+pT164+pY167
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. T159 and Y161 phosphorylation stimulate phosphotransferase activity. T164 and Y167 are putative phosphorylation sites that are predicted to be inhibitory.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: QPY-pT-E-pY-IS-pT-RW-pY-RAP
Peptide Modifications N Terminus: Free amino
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. T159 and Y161 phosphorylation stimulate phosphotransferase activity. T164 and Y167 are putative phosphorylation sites that are predicted to be inhibitory.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: QPY-pT-E-pY-IS-pT-RW-pY-RAP
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 2466.4 Da
Peptide Purity Percent after Synthesis and Purification: >50
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 2466.4 Da
Peptide Purity Percent after Synthesis and Purification: >50
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Scientific Background: MOK is a protein-serine/threonine kinase of the CMGC group and RCK family. Phosphorylation appears to increase its enzymatic activity. MOK belongs to the MAP kinase superfamily, and it may phosphorylate exogenous substrates or autophosphorylate. The protein may functions in regulation of cillium length and intraflagellar transport in renal epithelial cells. MOK may be a tumour requiring protein (TRP), since it displays extremely low rates of mutation in human cancers. MOK is a renal tumour antigen that is silent in most normal tissues except for retina and a number of tumour cell types.
© Kinexus Bioinformatics Corporation 2017