Product Name: MST3 (179-197) pT182+pT184+pT190+pT194
Product Number: PE-04AWP75
| Size: | 200 µg | Price: | 30.00 | |
| 1 mg | $US | 59.00 |
Peptide Name: MST3 (179-197) pT182+pT184+pT190+pT194
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. T190 phosphorylation stimulates phosphotransferase activity. T182 and T184 phosphorylation are predicted to be activatory, whereas T194 phosphorylation is predicted to be inhibitory.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: GQL-pT-D-pT-QIKRN-pT-FVG-pT-PFW
Peptide Modifications N Terminus: Free amino
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. T190 phosphorylation stimulates phosphotransferase activity. T182 and T184 phosphorylation are predicted to be activatory, whereas T194 phosphorylation is predicted to be inhibitory.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: GQL-pT-D-pT-QIKRN-pT-FVG-pT-PFW
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 2744.8 Da
Peptide Purity Percent after Synthesis and Purification: >50
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 2744.8 Da
Peptide Purity Percent after Synthesis and Purification: >50
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Scientific Background: MST3 (STK24) is a protein-serine/threonine kinase that is a member of the STE group of protein kinases in the STE20 family, and YSK subfamily. This kinase is highly expressed and widely distributed in most tested human tissues. MST3 promotes apoptosis in response to stress stimuli and caspase activation. It indirectly activates JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14 ) to mediates oxidative-stress-induced apoptosis. MST3 contains a conserved kinase domain at its N-terminus and a regulatory domain at its C-terminus. Caspase-mediated cleavage of the regulatory domain of MST3 activates its intrinsic kinase activity and leads to its nuclear translocation. Expression of C-terminal truncated MST3 in cells results in DNA fragmentation and induction of apoptosis. MST3 can inhibit cell migration in a fashion dependent on autophosphorylation and can regulate paxillin phosphorylation through protein-tyrosine phosphatase PTP-PEST. It has been implicated a key regulator of axon regeneration in the optic nerve and radial nerve.
© Kinexus Bioinformatics Corporation 2017