Product Name: CDK11 (581-587) pY582+pT583
Product Number: PE-04AWX99
| Size: | 200 µg | Price: | 41.00 | |
| 1 mg | $US | 83.00 |
Peptide Name: CDK11 (581-587) pY582+pT583
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The presentation as a dimer increases the potential activity. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. Y582+T583 phosphorylation is predicted to stimulate phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: (A-pY-pT-PVVV-pT-βA-Cys)2
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The presentation as a dimer increases the potential activity. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. Y582+T583 phosphorylation is predicted to stimulate phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: (A-pY-pT-PVVV-pT-βA-Cys)2
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Modifications Other: Phosphorylated, dimer
Peptide Molecular Mass Calculated: 2606.4 Da
Peptide Purity Percent after Synthesis and Purification: <50
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Storage Stability: Not stable
Peptide Molecular Mass Calculated: 2606.4 Da
Peptide Purity Percent after Synthesis and Purification: <50
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Storage Stability: Not stable
Scientific Background: CDK11 (CDK19, CD2L6) is a protein-serine/threonine kinase of the CMGC group and CDK family. It is a protein kinase that is a component of Mediator coactivator complex, which is required for transcriptional activation. It has cyclin-dependent protein serine/threonine kinase activity. RT-PCR ELISA detected highest expression was in corpus callosum, followed by kidney and ovary. Phosphorylation at T436 or Y437 inactivates CDK11, while phosphorylation at T583 activates it.
© Kinexus Bioinformatics Corporation 2017