Product Name: p38d MAPK (177-183) pT180+pY182
Product Number: PE-04BAQ00
| Size: | 200 µg | Price: | 13.00 | |
| 1 mg | $US | 27.00 |
Peptide Name: p38d MAPK (177-183) pT180+pY182
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases and for epitope mapping of phosphosite-specific antibodies. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. T180 and Y182 phosphorylation are predicted to be stimulatory for phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: AEM-pT-G-pY-V
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases and for epitope mapping of phosphosite-specific antibodies. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. T180 and Y182 phosphorylation are predicted to be stimulatory for phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: AEM-pT-G-pY-V
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 928.82 Da
Peptide Purity Percent after Synthesis and Purification: >50
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Molecular Mass Calculated: 928.82 Da
Peptide Purity Percent after Synthesis and Purification: >50
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Scientific Background: p38d (MAPK13) is a protein-serine/threonine kinase that is essential for MAP kinase signalling. p38d signalling can be induced via physical stress or proinflammatory cytokines resulting in the activation of the transcription factors ELK1 and ATF2. Cellular stress or pro-inflammatory cytokines can induce p38d-mediated activity. p38d is activated by cytokines and stresses and affects proliferation, differentiation, transcription regulation, translation regulation, cytoskeleton regulation, insulin secretion, cell survival and development. p38d can be a positive or negative regulator of the above processes depending on the cell context. Increased expression of p38d has been associated with increases proliferation and metastatic progression. It is also hypermethylated in some cancer cell lines. The rare liver cancer Cholangiocarcinoma (CCA, CC) has been noted to have a significant up-regulation of p38d compared to normal bile duct tissue. Insulin secretion and pancreatic beta cell survival can be regulated by p38d. The phosphotransferase activity of p38d can be abrogated with a T180A or a Y182A mutation.
© Kinexus Bioinformatics Corporation 2017