Product Name: ULK2
Product Number: AB-NK354-1
| Size: | 25 µg | Price: | 89.00 | |
| $US |
Target Full Name: Unc 51 (C. elegans) like kinase 2
Target Alias: Serine/threonine-protein kinase ULK2; EC:2.7.11.1; ULK2_HUMAN; KIAA0623; ATG1B; Serine/threonine protein kinase ULK2; Unc-51-like kinase 2; Unc 51 like autophagy activating kinase 2; Unc51.2; ULK2; Unc 51 like kinase 2;
Product Type Specific: Protein kinase pan-specific antibody
Antibody Code: NK354-1
Antibody Target Type: Pan-specific
Protein UniProt: Q8IYT8
Protein SigNET: Q8IYT8
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Target Alias: Serine/threonine-protein kinase ULK2; EC:2.7.11.1; ULK2_HUMAN; KIAA0623; ATG1B; Serine/threonine protein kinase ULK2; Unc-51-like kinase 2; Unc 51 like autophagy activating kinase 2; Unc51.2; ULK2; Unc 51 like kinase 2;
Product Type Specific: Protein kinase pan-specific antibody
Antibody Code: NK354-1
Antibody Target Type: Pan-specific
Protein UniProt: Q8IYT8
Protein SigNET: Q8IYT8
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Immunogen Source: Synthetic peptide from the mid-protein of Human ULK2 (AA 558-569)
Production Method: Peptide Affinity purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting
Production Method: Peptide Affinity purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting
Antibody Dilution Recommended: WB (1:1000); optimal dilutions for assays should be determined by the user.
Antibody Potency: Detects a strong ~113 kDa protein band in HeLa cell lysates.
Antibody Species Reactivity: Human | Rat
Antibody Positive Control: A 1:1000 dilution of SPC-641 was sufficient for detection of ULK2 in 15 µg of Human HeLa cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Antibody Specificity: Very high
Antibody Cross Reactivity: No other prominent cross-reactive proteins in mouse brain and HeLa cell lysates.
Related Product 1: ULK1 pan-specific antibody (Cat. No.: AB-NK298-2)
Related Product 2: ULK3 pan-specific antibody (Cat. No.: AB-NK355-1)
Antibody Potency: Detects a strong ~113 kDa protein band in HeLa cell lysates.
Antibody Species Reactivity: Human | Rat
Antibody Positive Control: A 1:1000 dilution of SPC-641 was sufficient for detection of ULK2 in 15 µg of Human HeLa cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Antibody Specificity: Very high
Antibody Cross Reactivity: No other prominent cross-reactive proteins in mouse brain and HeLa cell lysates.
Related Product 1: ULK1 pan-specific antibody (Cat. No.: AB-NK298-2)
Related Product 2: ULK3 pan-specific antibody (Cat. No.: AB-NK355-1)
Scientific Background: UNC-51 like kinase 2 (ULK2) is widely expresed and contains an amino-terminal kinase domain followed by a central proline-serine rich domain and a highly conserved carboxy-terminal domain. It has been linked to axon growth and is essential for autophagy. Structurally, ULK2 is similar to ATG1.
References
[1] Okazaki N. et al. (2000) Brain Res Mol Brain Res. 85: 1-12.
[2] Young A.R. et al. (2006) J Cell Sci. 119: 3888-900.
[3] Kamada Y. et al. (2000) J Cell Biol. 150: 1507-13.
[4] Lee S.B et al. (2007) EMBO Rep. 8: 360-5.
[5] Hara T. et al. (2008) J Cell Biol. 181: 497-510.
[1] Okazaki N. et al. (2000) Brain Res Mol Brain Res. 85: 1-12.
[2] Young A.R. et al. (2006) J Cell Sci. 119: 3888-900.
[3] Kamada Y. et al. (2000) J Cell Biol. 150: 1507-13.
[4] Lee S.B et al. (2007) EMBO Rep. 8: 360-5.
[5] Hara T. et al. (2008) J Cell Biol. 181: 497-510.
© Kinexus Bioinformatics Corporation 2017