Product Name: Copper Transporting ATPase 2
Product Number: AB-NN215-2
| Size: | 25 µg | Price: | 89.00 | |
| $US |
Target Full Name: ATPase Cu(2+) transporting beta polypeptide; Copper pump 2
Target Alias: ATP7B; ATPase Cu++ transporting beta polypeptide; ATPase Cu(2+) transporting beta polypeptide; Copper pump 2; Copper transporting ATPase 2; PWD; Toxic milk; tx; WC1; WD; Wilson disease associated protein; WND; WND/140 kDa
Product Type Specific: Copper transport protein pan-specific antibody
Antibody Code: NN215-2
Antibody Target Type: Pan-specific
Protein UniProt: B7ZLR4
Protein SigNET: B7ZLR4
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG1
Target Alias: ATP7B; ATPase Cu++ transporting beta polypeptide; ATPase Cu(2+) transporting beta polypeptide; Copper pump 2; Copper transporting ATPase 2; PWD; Toxic milk; tx; WC1; WD; Wilson disease associated protein; WND; WND/140 kDa
Product Type Specific: Copper transport protein pan-specific antibody
Antibody Code: NN215-2
Antibody Target Type: Pan-specific
Protein UniProt: B7ZLR4
Protein SigNET: B7ZLR4
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG1
Antibody Immunogen Source: Synthetic peptide amino acids 3-21 (cytoplasmic N-terminus) of human Copper-transporting ATPase2
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Immunohistochemistry | Immunoprecipitation
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Immunohistochemistry | Immunoprecipitation
Antibody Dilution Recommended: WB (1:1000); optimal dilutions for assays should be determined by the user.
Antibody Potency: This antibody detects a ~160 kDa protein in rat brain membrane preparations.
Antibody Species Reactivity: Human | Mouse | Rat
Antibody Positive Control: 1 µg/ml of SMC-399 was sufficient for detection of Copper-transporting ATPase2 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat IgG:HRP as the secondary antibody.
Antibody Specificity: High
Antibody Cross Reactivity: Three minor cross-reactive proteins in mouse brain lysates.
Related Product 1: Copper Transporting ATPase 1 pan-specific antibody (Cat. No.: AB-NN215-1)
Antibody Potency: This antibody detects a ~160 kDa protein in rat brain membrane preparations.
Antibody Species Reactivity: Human | Mouse | Rat
Antibody Positive Control: 1 µg/ml of SMC-399 was sufficient for detection of Copper-transporting ATPase2 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat IgG:HRP as the secondary antibody.
Antibody Specificity: High
Antibody Cross Reactivity: Three minor cross-reactive proteins in mouse brain lysates.
Related Product 1: Copper Transporting ATPase 1 pan-specific antibody (Cat. No.: AB-NN215-1)
Scientific Background: The copper efflux transporters ATP7A and ATP7B sequester intracellular copper into the vesicular secretory pathway for export from the cell. ATP7b is an important protein for copper transport and elimination of excess copper from the body. ATP7b transports metals in and out of cells using ATP. There are 3 known isoforms of the ATP7b gene; A is found in the liver, kidney, and brain, the shorter form B is found in brain tissue, and the third isoform, known as WND/140 KDA is found in mitochondria. Mutations in the ATP7b gene can cause Wilson's disease, an inherited disorder causing copper poisoning in the brain and liver, characterized by neurological symptoms and hepatic damage.
© Kinexus Bioinformatics Corporation 2017