Product Name: GluA1/GluR1 Glutamate Receptor
Product Number: AB-NN263-1
| Size: | 25 µg | Price: | 89.00 | |
| $US |
Target Full Name: AMPA selective glutamate receptor 1
Target Alias: AMPA 1; Glutamate receptor 1; GluA1; GLUH 1; GluR K1; GluRK1; Glr-1; Glur-1; HIPA; Glur1; GluR-A; AI853806; 2900051M01Rik; GluRA; Glr1; MGC13325; GLUH1; GluA1; GLUR1; HBGR1; GLURA; gluR-; GluA1; Glutamate receptor ionotropic AMPA 1; Glutamate receptor ionotropic; Gria 1; HBGR1; OTTHUMP00000160643; OTTHUMP00000165781; OTTHUMP00000224241; OTTHUMP00000224242; OTTHUMP00000224243
Product Type Specific: Calcium channel pan-specific antibody
Antibody Code: NN263-1
Antibody Target Type: Pan-specific
Protein UniProt: P42261
Protein SigNET: P42261
Antibody Type: Monoclonal
Target Alias: AMPA 1; Glutamate receptor 1; GluA1; GLUH 1; GluR K1; GluRK1; Glr-1; Glur-1; HIPA; Glur1; GluR-A; AI853806; 2900051M01Rik; GluRA; Glr1; MGC13325; GLUH1; GluA1; GLUR1; HBGR1; GLURA; gluR-; GluA1; Glutamate receptor ionotropic AMPA 1; Glutamate receptor ionotropic; Gria 1; HBGR1; OTTHUMP00000160643; OTTHUMP00000165781; OTTHUMP00000224241; OTTHUMP00000224242; OTTHUMP00000224243
Product Type Specific: Calcium channel pan-specific antibody
Antibody Code: NN263-1
Antibody Target Type: Pan-specific
Protein UniProt: P42261
Protein SigNET: P42261
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG1
Antibody Immunogen Source: Fusion protein amino acids 1-389 (extracellular N-terminus) of rat GluA1/GluR1
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 50% glycerol, 0.1% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Antibody Ig Isotype Clone: IgG1
Antibody Immunogen Source: Fusion protein amino acids 1-389 (extracellular N-terminus) of rat GluA1/GluR1
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH 7.4, 50% glycerol, 0.1% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence
Antibody Dilution Recommended: WB (1:1000); optimal dilutions for assays should be determined by the user.
Antibody Potency: Detects a ~100 kDa protein in cell and tissue lysates by Western blotting.
Antibody Species Reactivity: Mouse | Rat
Antibody Positive Control: 1 µg/ml of SMC-440 was sufficient for detection of GluA1/GluR1 in 20 µg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Antibody Cross Reactivity: Does not cross-react with GluR2.
Related Product 1: GluN1/NR1 pan-specific antibody (Cat. No.: AB-NN264-1)
Antibody Dilution Recommended: WB (1:1000); optimal dilutions for assays should be determined by the user.
Antibody Potency: Detects a ~100 kDa protein in cell and tissue lysates by Western blotting.
Antibody Species Reactivity: Mouse | Rat
Antibody Positive Control: 1 µg/ml of SMC-440 was sufficient for detection of GluA1/GluR1 in 20 µg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Antibody Cross Reactivity: Does not cross-react with GluR2.
Related Product 1: GluN1/NR1 pan-specific antibody (Cat. No.: AB-NN264-1)
Related Product 2: GluN2A/NR2A pan-specific antibody (Cat. No.: AB-NN297-2)
Related Product 3: GluN2A/NR2A pan-specific antibody (Cat. No.: AB-NN297-1)
Related Product 3: GluN2A/NR2A pan-specific antibody (Cat. No.: AB-NN297-1)
Scientific Background: Glutamic acid is the major excitatory neurotransmitter in the mammalian central nervous system. Glutamate receptors are classified on the basis of their activation by different agonists (1-3). GluR1, human glutamate receptor type 1, is an integral membrane protein that is widely expressed in the human brain. The postsynaptic actions of glutamic acid are mediated by a variety of receptors that are named according to their selective agonists. GluR1 is known to bind a kainate subtype of agonist. It has been found that malfunctioning of the glutamatergic system may result in certain brain disorders and neurodegeneration (3).
References
[1] Potier M.C., Spillantini M.G., Carter N.P. (1992) DNA Seq. 2(4): 211-218.
[2] Puckett, C. et al. (1991) Proc. Nat. Acad. Sci. USA 88(17): 7557-7561.
[3] Gregor, P. et al. (1993) Proc. Nat. Acad. Sci. USA 90: 3053-3057.
[1] Potier M.C., Spillantini M.G., Carter N.P. (1992) DNA Seq. 2(4): 211-218.
[2] Puckett, C. et al. (1991) Proc. Nat. Acad. Sci. USA 88(17): 7557-7561.
[3] Gregor, P. et al. (1993) Proc. Nat. Acad. Sci. USA 90: 3053-3057.
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