Product Name: GluN1/NR1
Product Number: AB-NN264-1
| Size: | 25 µg | Price: | 89.00 | |
| $US |
Target Full Name: Glutamate receptor ionotropic, NMDA 1
Target Alias: NMDAR1; NMDA Receptor 1; NMDAR; NMDA1; GRIN1; Glutamate [NMDA] receptor subunit zeta-1; Glutamate receptor ionotropic N methyl D aspartate 1; MRD8; N methyl D aspartate receptor; N methyl D aspartate receptor channel subunit zeta 1; N methyl D aspartate receptor subunit NR1; NMD-R1; NMDA 1; NMDA R1; NMDZ1_HUMAN; NR1; GluN1
Product Type Specific: Calcium channel pan-specific antibody
Antibody Code: NN264-1
Antibody Target Type: Pan-specific
Protein UniProt: Q05586
Protein SigNET: Q05586
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Target Alias: NMDAR1; NMDA Receptor 1; NMDAR; NMDA1; GRIN1; Glutamate [NMDA] receptor subunit zeta-1; Glutamate receptor ionotropic N methyl D aspartate 1; MRD8; N methyl D aspartate receptor; N methyl D aspartate receptor channel subunit zeta 1; N methyl D aspartate receptor subunit NR1; NMD-R1; NMDA 1; NMDA R1; NMDZ1_HUMAN; NR1; GluN1
Product Type Specific: Calcium channel pan-specific antibody
Antibody Code: NN264-1
Antibody Target Type: Pan-specific
Protein UniProt: Q05586
Protein SigNET: Q05586
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG1
Antibody Immunogen Source: Fusion protein amino acids 42-361 (extracellular N-terminus) of rat NR1
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence
Antibody Immunogen Source: Fusion protein amino acids 42-361 (extracellular N-terminus) of rat NR1
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence
Antibody Dilution Recommended: WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Antibody Potency: Detects a ~105 kDa protein in cell and tissue lysates by Western blotting.
Antibody Species Reactivity: Human | Mouse | Rat
Antibody Positive Control: 1 µg/ml of SMC-410 was sufficient for detection of NR1 glutamate receptor in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Related Product 1: GluA1/GluR1 Glutamate Receptor pan-specific antibody (Cat. No.: AB-NN263-1)
Related Product 2: GluN2A/NR2A pan-specific antibody (Cat. No.: AB-NN297-2)
Antibody Potency: Detects a ~105 kDa protein in cell and tissue lysates by Western blotting.
Antibody Species Reactivity: Human | Mouse | Rat
Antibody Positive Control: 1 µg/ml of SMC-410 was sufficient for detection of NR1 glutamate receptor in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Related Product 1: GluA1/GluR1 Glutamate Receptor pan-specific antibody (Cat. No.: AB-NN263-1)
Related Product 2: GluN2A/NR2A pan-specific antibody (Cat. No.: AB-NN297-2)
Scientific Background: The NMDA receptor (NMDAR), a glutamate receptor, is the predominant molecular device for controlling synaptic plasticity and memory function (1). The NMDA receptor forms a heterotetramer between two NR1 and two NR2 subunits (the subunits are also called glutamate-binding NMDA receptor subunits or GluN for short); two obligatory NR1 subunits and two regionally localized NR2 subunits. A related gene family of NR3 A and B subunits have an inhibitory effect on receptor activity. Multiple receptor isoforms with distinct brain distributions and functional properties arise by selective splicing of the NR1 transcripts and differential expression of the NR2 subunits.
References
[1] Li F., and Tsien J.Z. (2009) New England J. Medicine. 361: 302-303.
[2] Garcia-Gallo M., Renart J., Diaz-Guerra M. (2001) Biochem J. 356: 539-547.
[3] Atlason P.T., Garside M.L., Meddows E., Whiting P., McIllhinney R.A.J. (2007) J Biol Chem. 282(35): 25299-25307.
[1] Li F., and Tsien J.Z. (2009) New England J. Medicine. 361: 302-303.
[2] Garcia-Gallo M., Renart J., Diaz-Guerra M. (2001) Biochem J. 356: 539-547.
[3] Atlason P.T., Garside M.L., Meddows E., Whiting P., McIllhinney R.A.J. (2007) J Biol Chem. 282(35): 25299-25307.
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