Product Name: Nav beta 2
Product Number: AB-NN314-1
| Size: | 25 µg | Price: | 89.00 | |
| $US |
Target Full Name: Sodium channel subunit beta-2
Target Alias: Scn2b; UNQ326/PRO386; Gm183
Product Type Specific: Sodium channel pan-specific antibody
Antibody Code: NN314-1
Antibody Target Type: Pan-specific
Protein UniProt: O60939
Protein SigNET: O60939
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG2B
Antibody Immunogen Source: Fusion protein amino acids 1-215 (full-length) of mouse NavBeta2
Target Alias: Scn2b; UNQ326/PRO386; Gm183
Product Type Specific: Sodium channel pan-specific antibody
Antibody Code: NN314-1
Antibody Target Type: Pan-specific
Protein UniProt: O60939
Protein SigNET: O60939
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG2B
Antibody Immunogen Source: Fusion protein amino acids 1-215 (full-length) of mouse NavBeta2
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.1% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence
Antibody Dilution Recommended: WB (1:1000); optimal dilutions for assays should be determined by the user.
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.1% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence
Antibody Dilution Recommended: WB (1:1000); optimal dilutions for assays should be determined by the user.
Antibody Potency: In mouse brain lysates, this antibody detects a ~40 kDa protein by Western blotting.
Antibody Species Reactivity: Human | Mouse | Rat
Antibody Positive Control: A 1:100 dilution of SMC-485 was sufficient for detection of NavBeta2 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Antibody Specificity: High
Antibody Cross Reactivity: Does not cross-reat with NavBeta1, Navbeta3, or Navbeta4. One very strong ~75 kDa immuno-reactive protein.
Related Product 1: Nav beta 3 pan-specific antibody (Cat. No.: AB-NN315-1)
Antibody Species Reactivity: Human | Mouse | Rat
Antibody Positive Control: A 1:100 dilution of SMC-485 was sufficient for detection of NavBeta2 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Antibody Specificity: High
Antibody Cross Reactivity: Does not cross-reat with NavBeta1, Navbeta3, or Navbeta4. One very strong ~75 kDa immuno-reactive protein.
Related Product 1: Nav beta 3 pan-specific antibody (Cat. No.: AB-NN315-1)
Scientific Background: NavBeta2 or Scn2B, plays a crucial role in the assembly, expression and functional modulation of the heterotrimeric complex of the sodium channel. The subunit, beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. It also interacts with TNR, playing a crucial role in clustering and regulation of activity of sodium channels at the nodes of Ranvier (1, 2). Mutations in this gene have been linked to Brugada syndrome and atrial fibrillation (3).
References
[1] Genes and mapped phenotypes. (n.d.). Retrieved March 16, 2015, from http://www.ncbi.nlm.nih.gov/gene/6327
[2] Eubanks J., Srinivasan J., Dinulos M.B., Disteche C.M., Catterall W.A. (1997) Neuroreport. 8(12): 2775-2779.
[3] Riuro H. et al. (2013) Hum Mutat. 34(7): 961-966.
[1] Genes and mapped phenotypes. (n.d.). Retrieved March 16, 2015, from http://www.ncbi.nlm.nih.gov/gene/6327
[2] Eubanks J., Srinivasan J., Dinulos M.B., Disteche C.M., Catterall W.A. (1997) Neuroreport. 8(12): 2775-2779.
[3] Riuro H. et al. (2013) Hum Mutat. 34(7): 961-966.
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