Product Name: Nav beta 3
Product Number: AB-NN315-1
Size: 25 µg      Price:89.00
      $US
Target Full Name: Sodium channel subunit beta-3

Target Alias: Scn3b; KIAA1158

Product Type Specific: Sodium channel pan-specific antibody

Antibody Code: NN315-1

Antibody Target Type: Pan-specific

Protein UniProt: Q9NY72

Protein SigNET: Q9NY72

Antibody Type: Monoclonal

Antibody Host Species: Mouse

Antibody Ig Isotype Clone: IgG2B

Antibody Immunogen Source: Fusion protein amino acids 1-215 (full-length) of rat NavBeta3

Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.

Antibody Concentration: 1 mg/ml

Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.1% sodium azide

Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.

Product Use: Western blotting | ICC/Immunofluorescence

Antibody Dilution Recommended: WB (1:1000); optimal dilutions for assays should be determined by the user.

Antibody Potency: In mouse brain lysates, this antibody detects a ~40 kDa protein by Western blotting.

Antibody Species Reactivity: Mouse | Rat

Antibody Positive Control: A 1:100 dilution of SMC-490 was sufficient for detection of NavBeta3 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Antibody Specificity: Very high

Antibody Cross Reactivity: Does not cross-reat with NavBeta1, Navbeta2, or Navbeta4.

Related Product 1: Nav beta 2 pan-specific antibody (Cat. No.: AB-NN314-1)

Scientific Background: Nav Beta 3 (SCN3B) belongs to the voltage-gated sodium channel group, and modulates channel gating kinetics. It inactivates the sodium channel opening more slowly than its Beta1 subunit. It is also unique in causing persistent sodium currents which are thought to amplify summation of synaptic imputs which is likely to increase the excitability of specific neurons to their individual inputs (2). Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (1, 2). Defects in SCN3B are the cause of Brugada syndrome (3).