Product Name: MEK3 (333-347)
Product Number: PE-01AWD99
Size: 200 µg      Price:29.00
1 mg      $US57.00
Peptide Name: MEK3 (333-347)

Product Use: Services as a blocking peptide for use with the MKK3-3 rabbit polyclonal antibody (Cat. No.: AB-NK101-6) that is also available from Kinexus. The peptide sequence is located in the C-terminus. The presentation as a dimer increases the potential activity.

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Homo sapiens

Peptide Sequence: (CTDIAAFVKEILGEDS)2

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: Free carboxyl

Peptide Molecular Mass Calculated: 3717.8 Da

Peptide Purity Percent after Synthesis and Purification: >50

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Related Product 1: MEK3 pan-specific antibody (Cat. No.: AB-NK101-6)

Scientific Background: MKK3 (MAP2K3, MEK3) is a Dual specificity protein kinase of the STE group and STE7 family. MKK3 is activated by cytokines and environmental stress in vivo. Phosphorylation of S218 and T222 increases its phosphotransferase activity. S218A and T222A substitutions are involved in inactivation. S218E and T222E mutations are associated in constitutive activation. It catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the activation T loops of the p38 MAP kinase isoforms. Defects in the MKK3 gene may be involved colon cancer.