Product Name: IKKb (716-735)
Product Number: PE-01BDG99
Size: | 200 µg | | Price: | 64.00 |
| 1 mg | | $US | 128.00 |
| 5 mg | | | 280.00 |
Peptide Name: IKKb (716-735)
Product Use: Services as a blocking peptide for use with the IKKb-BCT rabbit polyclonal antibody (Cat. No.: AB-NK076-5) that is also available from Kinexus. The peptide sequence is located in the pre-C-terminus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CTLLENAIQDTVREQDQSFT
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 2310.5 Da
Peptide Purity Percent after Synthesis and Purification: >95
Scientific Background: IKKb (IKBKB) is a protein-serine/threonine kinase of the Other group and IKK family. It functions in NF-kappa-B signalling and is activated by various indicators of cellular stress, including inflammatory cytokines, bacterial or viral products, and DNA damage. The activity of the kinase enables for NF-kappa-B to enter the nucleus and stimulate the transcription of genes involved in the immune response, control of cell growth, and cellular protection against apoptosis. IKKb may be a tumour requiring protein (TRP), since it displays extremely low rates of mutation in human cancers.