Product Name: ICK (152-158) pY156+pT157
Product Number: PE-04ABV99
| Size: | 200 µg | Price: | 66.00 | |
| 1 mg | $US | 132.00 | ||
| 5 mg | 290.00 |
Peptide Name: ICK (152-158) pY156+pT157
Product Use: Services as a blocking peptide for use with the ICK-pY156+pT157 rabbit polyclonal antibody (Cat. No.: AB-PK655) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y156 and T157 phosphorylation stimulate phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: SKPP-pY-pT-D
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the ICK-pY156+pT157 rabbit polyclonal antibody (Cat. No.: AB-PK655) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y156 and T157 phosphorylation stimulate phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: SKPP-pY-pT-D
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1140 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: ICK - pY156+pT157 phosphosite-specific antibody (Cat. No.: AB-PK655)
Peptide Molecular Mass Calculated: 1140 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: ICK - pY156+pT157 phosphosite-specific antibody (Cat. No.: AB-PK655)
Scientific Background: ICK is a protein-serine/threonine kinase of the CMGC group and RCK family. It displays sequence similarity to the MAP kinases in the catalytic domain and the requirement for dual phosphorylation for activation within a MAP kinase-like TDY motif. ICK functions in the regulation of proliferation and differentiation in intestinal cells. Impairing ICK function has been shown to dowregulate the translation of specific targets of eIF4E and S6K1 (e.g. cyclin D1 and c-Myc) mediated through the mTOR/Raptor signalling pathway. Additionally, ICK homologuess in algae and invertebrates function in the formation of flagella and in ciliogenesis.
© Kinexus Bioinformatics Corporation 2017