Product Name: HSP90AB1 (481-487) pY484
Product Number: PE-04AFE99
Size: 200 µg      Price:47.00
1 mg      $US94.00
5 mg      206.00
Peptide Name: HSP90AB1 (481-487) pY484

Product Use: Services as a blocking peptide for use with the HSP90AB1-pY484 rabbit polyclonal antibody (Cat. No.: AB-PN520) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the middle of the HSP90 domain. This is the major in vivo phosphorylation site in HSP90AB1. The effect of its phosphorylation is unclear.

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Homo sapiens

Peptide Sequence: KSI-pY-YIT

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated

Peptide Molecular Mass Calculated: 1140.23 Da

Peptide Purity Percent after Synthesis and Purification: >95

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Related Product 1: HSP90AB1 - pY484 phosphosite-specific antibody (Cat. No.: AB-PN520)

Scientific Background: HSP90-beta is a molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in diverse cellular functions such as cycle control. It induces conformational changes in the client proteins in an ATP-dependent process as an ATPase, and causes their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.