Product Name: RSK3 (214-221) pY217+pS218
Product Number: PE-04AHU95
| Size: | 200 µg | Price: | 69.00 | |
| 1 mg | $US | 139.00 | ||
| 5 mg | 304.00 |
Peptide Name: RSK3 (214-221) pY217+pS218
Product Use: Services as a blocking peptide for use with the RSK3-pY217+pS218 rabbit polyclonal antibody (Cat. No.: AB-PK808) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. Y217 and S218 phosphorylation are predicted to be stimulatory for phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: KRA-pY-pS-FCG
Peptide Modifications N Terminus: Free amino
Product Use: Services as a blocking peptide for use with the RSK3-pY217+pS218 rabbit polyclonal antibody (Cat. No.: AB-PK808) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. Y217 and S218 phosphorylation are predicted to be stimulatory for phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: KRA-pY-pS-FCG
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1264.26 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: RSK3 - pY217+pS218 phosphosite-specific antibody (Cat. No.: AB-PK808)
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1264.26 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: RSK3 - pY217+pS218 phosphosite-specific antibody (Cat. No.: AB-PK808)
Scientific Background: RSK3 (RPS6KA2) is a protein-serine/threonine kinase of the AGC group and RSK family. It is a protein-serine/threonine kinase member of the RSK (ribosomal S6 kinase) family of growth factor-regulated kinases. RSK proteins have two kinase catalytic domains and are phosphorylated by MAPK proteins in response to growth factors, polypeptide hormones, and neurotransmitters. RSK3 is activated by multiple phosphorylations on threonine and serine residues. Phosphorylation at S360 increases phosphotransferase activity. Phosphorylation at S218 inhibits interaction with AKAP6. RSK3 acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signalling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. It may function as tumour suppressor in epithelial ovarian cancer cells.
© Kinexus Bioinformatics Corporation 2017