Product Name: CDK11 (580-586) pT583
Product Number: PE-04AJJ95
| Size: | 200 µg | Price: | 42.00 | |
| 1 mg | $US | 84.00 | ||
| 5 mg | 185.00 |
Peptide Name: CDK11 (580-586) pT583
Product Use: Services as a blocking peptide for use with the CDK11A-pT583 rabbit polyclonal antibody (Cat. No.: AB-PK565) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. T583 phosphorylation is predicted to be stimulatory for phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: KAY-pT-PVV
Peptide Modifications N Terminus: Free amino
Product Use: Services as a blocking peptide for use with the CDK11A-pT583 rabbit polyclonal antibody (Cat. No.: AB-PK565) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. T583 phosphorylation is predicted to be stimulatory for phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: KAY-pT-PVV
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1031.1 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: CDK11 - pT583 phosphosite-specific antibody (Cat. No.: AB-PK565)
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1031.1 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: CDK11 - pT583 phosphosite-specific antibody (Cat. No.: AB-PK565)
Scientific Background: CDK11 (CDK19, CD2L6) is a protein-serine/threonine kinase of the CMGC group and CDK family. It is a protein kinase that is a component of Mediator coactivator complex, which is required for transcriptional activation. It has cyclin-dependent protein serine/threonine kinase activity. RT-PCR ELISA detected highest expression was in corpus callosum, followed by kidney and ovary. Phosphorylation at T436 or Y437 inactivates CDK11, while phosphorylation at T583 activates it.
© Kinexus Bioinformatics Corporation 2017