Product Name: AAK1 (634-640) pS637
Product Number: PE-04ALP99
| Size: | 200 µg | Price: | 42.00 | |
| 1 mg | $US | 84.00 | ||
| 5 mg | 185.00 |
Peptide Name: AAK1 (634-640) pS637
Product Use: Services as a blocking peptide for use with the AAK1-pS637 rabbit polyclonal antibody (Cat. No.: AB-PK503) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the C-terminal half of the kinase after the catalytic domain. The major site of phosphorylation of AAK1. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: RIL-pS-DVT
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the AAK1-pS637 rabbit polyclonal antibody (Cat. No.: AB-PK503) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the C-terminal half of the kinase after the catalytic domain. The major site of phosphorylation of AAK1. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: RIL-pS-DVT
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1057.1 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: AAK1 - pS637 phosphosite-specific antibody (Cat. No.: AB-PK503)
Peptide Molecular Mass Calculated: 1057.1 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: AAK1 - pS637 phosphosite-specific antibody (Cat. No.: AB-PK503)
Scientific Background: AAK1 is a protein-serine/threonine kinase of the Other group and NAK family. It stimulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) to ensure high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. AAK1 also targets the phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. It phosphorylates NUMB and promotes NUMB localization to endosomes. It also binds and stabilizes the activated form of NOTCH1 to increases its localization in endosomes. Insertional mutagenesis studies in mice support a role for this protein kinase in mouse cancer oncogenesis.
© Kinexus Bioinformatics Corporation 2017