Product Name: IKKe (169-175) pS172
Product Number: PE-04AMW99
| Size: | 200 µg | Price: | 42.00 | |
| 1 mg | $US | 84.00 | ||
| 5 mg | 185.00 |
Peptide Name: IKKe (169-175) pS172
Product Use: Services as a blocking peptide for use with the IKKe-pS172 rabbit polyclonal antibody (Cat. No.: AB-PK660) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. S172 phosphorylation stimulates phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: KFV-pS-VYG
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the IKKe-pS172 rabbit polyclonal antibody (Cat. No.: AB-PK660) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. S172 phosphorylation stimulates phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: KFV-pS-VYG
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1052.13 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: IKKe - pS172 phosphosite-specific antibody (Cat. No.: AB-PK660)
Peptide Molecular Mass Calculated: 1052.13 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: IKKe - pS172 phosphosite-specific antibody (Cat. No.: AB-PK660)
Scientific Background: IKKe (IKBKE) is a protein-serine/threonine kinase of the Other group and IKK family. It mediates inflammatory responses in response to viral infections (type I IFN, NF-kB, STAT, TNFa, and IL-1 signalling). Phosphorylation at S172 increases phosphotransferase activity. Ubiquitination and decreased kinase phosphotransferase activity stems from a K30A, or K401A, or K30R, or K401R mutation in IKKe. K30R and K401R will additionally reduce interactions with IKKb, IKBKG, and MyD88. The K38A mutation leads to kinase phosphotransferase activity inhibition and inhibited nuclear transport. Sumoylation and targeting to nuclear bodies is lost with a K231R mutation to IKKe.
© Kinexus Bioinformatics Corporation 2017