Product Name: SMG1 (3547-3553) pT3550
Product Number: PE-04APQ99
| Size: | 200 µg | Price: | 42.00 | |
| 1 mg | $US | 84.00 | ||
| 5 mg | 185.00 |
Peptide Name: SMG1 (3547-3553) pT3550
Product Use: Services as a blocking peptide for use with the SMG1-pT3550 rabbit polyclonal antibody (Cat. No.: AB-PK817) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the C-terminus of SMG1. This is one of the two major in vivo sites for phosphorylation of SMG1. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: GQK-pT-QPD
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the SMG1-pT3550 rabbit polyclonal antibody (Cat. No.: AB-PK817) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the C-terminus of SMG1. This is one of the two major in vivo sites for phosphorylation of SMG1. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: GQK-pT-QPD
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1026 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: SMG1 - pT3550 phosphosite-specific antibody (Cat. No.: AB-PK817)
Peptide Molecular Mass Calculated: 1026 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: SMG1 - pT3550 phosphosite-specific antibody (Cat. No.: AB-PK817)
Scientific Background: SMG1 (ATX) is a protein-serine/threonine kinase of the Atypical group and PIKK family. It mediates the genotoxic stress pathway as well as the mRNA surveillance pathway. SMG1 will target nonsense RNA molecules for degradation via phosphorylation of RENT1/UPF1. SMG1 is essential for optimal phosphorylation and activity of p53/TP53 following genotoxic stress. It is iInhibited by caffeine, LY294002 and wortmannin.
© Kinexus Bioinformatics Corporation 2017