Product Name: TNK1 (274-280) pY277
Product Number: PE-04AQC80
| Size: | 200 µg | Price: | 35.00 | |
| 1 mg | $US | 71.00 | ||
| 5 mg | 153.00 |
Peptide Name: TNK1 (274-280) pY277
Product Use: Services as a blocking peptide for use with the TNK1-pY277 rabbit polyclonal antibody (Cat. No.: AB-PK832) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y277 phosphorylation is predicted to stimulate phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: RGR-pY-VMG
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the TNK1-pY277 rabbit polyclonal antibody (Cat. No.: AB-PK832) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y277 phosphorylation is predicted to stimulate phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: RGR-pY-VMG
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1091.2 Da
Peptide Purity Percent after Synthesis and Purification: >80
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: TNK1 - pY277 phosphosite-specific antibody (Cat. No.: AB-PK832)
Peptide Molecular Mass Calculated: 1091.2 Da
Peptide Purity Percent after Synthesis and Purification: >80
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: TNK1 - pY277 phosphosite-specific antibody (Cat. No.: AB-PK832)
Scientific Background: TNK1 is a protein-tyrosine kinase of the TK group and Ack family. It is a non-receptor kinase that functions as a negative regulator of cell growth through inhibition of the Ras-MAPK intracellular signalling pathway. TNK1 is thought to function in many tissues during fetal development and more selectively in the adult, with activity limited to cells of the lymphohematopoietic system. In addition, TNK1 is also predicted to play a role in phospholipid signalling. Phosphorylation of the TNK1 protein at several sites (Y77, Y235, Y277, Y287, and Y353) was observed in Hodgkin lymphoma (HL) cancer cell lines, indicating a possible role for the aberrant activity of the protein in the pathogenesis of this disease. In addition, a truncated form of TNK1 was identified in HL cancer cells. However, the effect of the truncation on its phosphotransferase activity was unclear.
© Kinexus Bioinformatics Corporation 2017