Product Name: Lck (257-268) pY263+pY264
Product Number: PE-04ARP55
| Size: | 200 µg | Price: | 20.00 | |
| 1 mg | $US | 39.00 | ||
| 5 mg | 107.00 |
Peptide Name: Lck (257-268) pY263+pY264
Product Use: Services as a blocking peptide for use with the Lck-pY263+pY264 rabbit polyclonal antibody (Cat. No.: AB-PK680) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the kinase catalytic domain between subdomains I and II. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: GEVWMG-pY-pY-NGHT
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the Lck-pY263+pY264 rabbit polyclonal antibody (Cat. No.: AB-PK680) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the kinase catalytic domain between subdomains I and II. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: GEVWMG-pY-pY-NGHT
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1788.72 Da
Peptide Purity Percent after Synthesis and Purification: >50
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Lck - pY263+pY264 phosphosite-specific antibody (Cat. No.: AB-PK680)
Peptide Molecular Mass Calculated: 1788.72 Da
Peptide Purity Percent after Synthesis and Purification: >50
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Lck - pY263+pY264 phosphosite-specific antibody (Cat. No.: AB-PK680)
Scientific Background: Lck is a non-receptor protein-tyrosine kinase of the TK group and Src family. Phosphorylation of Y394 increases phosphotransferase activity and induces interaction with Lck. Phosphorylation of Y192 and Y505 inhibits Lck phosphotransferase activity. Lck has a critical function in the selection and maturation of developing T-cells in the thymus, as well as in the function of mature T-cells throughout the body. Lck is a key signalling component of the T-cell antigen receptor (TCR)-linked signal transduction pathway and is constitutively bound to the cytoplasmic domains of the CD4 and CD8 membrane receptors. Lck is expressed through all stages of thymocyte development and is necessary for regulating both pre-TCR and mature alpha beta TCR-mediated maturation. Lck may be an oncoprotein (OP) based on its similarity to other Src family protein-tyrosine kinases.
© Kinexus Bioinformatics Corporation 2017