Product Name: Cav beta 1
Product Number: AB-NN222-1
Size: 25 µg      Price:89.00
      $US
Target Full Name: Voltage-dependent L-type calcium channel subunit beta-1

Target Alias: CACNB1; CAB1; CACNLB1; voltage dependent L type calcium channel beta 1 subunit

Product Type Specific: Calcium channel pan-specific antibody

Antibody Code: NN222-1

Antibody Target Type: Pan-specific

Protein UniProt: Q02641

Protein SigNET: Q02641

Antibody Type: Monoclonal

Antibody Host Species: Mouse

Antibody Ig Isotype Clone: IgG1

Antibody Immunogen Source: Synthetic peptide amino acids 19-34 of rat CavB1

Production Method: Protein G purified

Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.

Antibody Concentration: 1 mg/ml

Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide

Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.

Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence | Immunoprecipitation

Antibody Dilution Recommended: WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Antibody Potency: Medium potency. Detects ~80 and 55 kDa proteins in cell and tissue lysates by Western blotting.

Antibody Species Reactivity: Human | Mouse | Rat

Antibody Positive Control: 1 µg/ml of SMC-317 was sufficient for detection of Cavβ1 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Antibody Specificity: Very high

Antibody Cross Reactivity: No cross-reactivity against Cav Beta4.

Related Product 1: Cav beta 2 pan-specific antibody (Cat. No.: AB-NN228-1)

Related Product 2: Cav beta 4 pan-specific antibody (Cat. No.: AB-NN223-1)

Related Product 3: Cav1.2 pan-specific antibody (Cat. No.: AB-NN225-1)
Scientific Background: Calcium channel, voltage-dependent, beta 1 subunit, also known as CACNB1, is a human gene. The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified (1, 2).