Product Name: Cav1.2
Product Number: AB-NN225-1
Size: 25 µg      Price:89.00
      $US
Target Full Name: Voltage dependent L type calcium channel subunit alpha 1D

Target Alias: CACH3; CACN4; CACNA 1D; CACNL1A2; alpha-1 subunit voltage-dependent calcium channel; calcium channel voltage-dependent L type alpha 1C subunit1; voltage-gated calcium channel alpha subunit Cav1.2; calcium channel L type; alpha 1 polypeptide isoform 1 cardic muscle; calcium channel cardic dihydropyridine-sensitive alpha-1 subunit; voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit splice variant 10; DHPR alpha-1 subunit; Voltage-gated calcium channel subunit alpha Cav1.2; Calcium channel L type alpha-1 polypeptide isoform 1 cardiac muscle

Product Type Specific: Calcium channel pan-specific antibody

Antibody Code: NN225-1

Antibody Target Type: Pan-specific

Protein UniProt: P15381
Protein SigNET: P15381

Antibody Type: Monoclonal

Antibody Host Species: Mouse

Antibody Ig Isotype Clone: IgG1

Antibody Immunogen Source: Fusion protein amino acids 1507-1733 (intracellular carboxyl terminus) of rabbit Cav1.2

Production Method: Protein G purified

Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.

Antibody Concentration: 1 mg/ml

Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.1% sodium azide

Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.

Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence | Immunoprecipitation

Antibody Dilution Recommended: WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Antibody Potency: High potency. Detects a ~240 kDa protein (varies with cell background due to glycosylation).

Antibody Species Reactivity: Human | Mouse | Rat | Hamster

Antibody Positive Control: 1 µg/ml of SMC-300 was sufficient for detection of Cav1.2 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Antibody Specificity: Medium-High

Related Product 1: Cav beta 1 pan-specific antibody (Cat. No.: AB-NN222-1)

Related Product 2: Cav beta 2 pan-specific antibody (Cat. No.: AB-NN228-1)

Related Product 3: Cav beta 4 pan-specific antibody (Cat. No.: AB-NN223-1)

Related Product 4: Cav1.3 pan-specific antibody (Cat. No.: AB-NN226-1)

Related Product 5: Cav3.1 pan-specific antibody (Cat. No.: AB-NN227-1)

Scientific Background: Cav1.2 is a cardiac L-type calcium channel, and is important for excitation and contraction of the heart (1). It may be associated with a variant of Long QT syndrome called Timothy's syndrome (2, 3) and also with Brugada syndrome. Some references also suggest it is related to bipolar disease as well (3).