Product Name: Cav beta 2
Product Number: AB-NN228-1
Size: 25 µg      Price:89.00
      $US
Target Full Name: Voltage-dependent L-type calcium channel subunit beta-2

Target Alias: Cacnlb2; cacnb2; CAB2

Product Type Specific: Calcium channel pan-specific antibody

Antibody Code: NN228-1

Antibody Target Type: Pan-specific

Protein UniProt: Q08289

Protein SigNET: Q08289

Antibody Type: Monoclonal

Antibody Host Species: Mouse

Antibody Ig Isotype Clone: IgG1

Antibody Immunogen Source: Synthetic peptide amino acids 189-205 of rat CavBeta2

Production Method: Protein G purified

Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.

Antibody Concentration: 1 mg/ml

Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide

Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.

Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence | Immunoprecipitation

Antibody Dilution Recommended: WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Antibody Potency: High potency. Detects a ~78 kDa protein in cell and tissue lysates by Western blotting.

Antibody Species Reactivity: Human | Mouse | Rat

Antibody Positive Control: 1 µg/ml of SMC-332 was sufficient for detection of Cavβ2 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody

Antibody Specificity: Very high

Antibody Cross Reactivity: No cross reactivity against Cavβ1, Cavβ3, Cavβ4.

Related Product 1: Cav beta 1 pan-specific antibody (Cat. No.: AB-NN222-1)

Related Product 2: Cav beta 4 pan-specific antibody (Cat. No.: AB-NN223-1)

Related Product 3: Cav1.2 pan-specific antibody (Cat. No.: AB-NN225-1)
Scientific Background: Cav Beat subunits are involved in the transport of the pore forming alpha1 subunit to the plasma membrane (1). They also shield an ER Retention signal on the alpha1 subunit, thereby guiding the pore-forming subunit to the target membrane (2, 3). They also determine the biophysical properties of the calcium channel (3).