Product Name: GABA-A Receptor Epsilon
Product Number: AB-NN255-1
Size: 25 µg      Price:89.00
      $US
Target Full Name: Gamma-aminobutyric acid receptor subunit epsilon

Target Alias: Gamma-aminobutyric acid receptor epsilon subunit; GABRE

Product Type Specific: Chloride channel pan-specific antibody

Antibody Code: NN255-1

Antibody Target Type: Pan-specific

Protein UniProt: P78334

Protein SigNET: P78334

Antibody Type: Monoclonal

Antibody Host Species: Mouse

Antibody Ig Isotype Clone: IgG2A

Antibody Immunogen Source: Fusion protein amino acids 27-253 (Extracellular N-terminus) of human GABA-A Receptor Epsilon

Production Method: Protein G purified

Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.

Antibody Concentration: 1 mg/ml

Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.1% sodium azide

Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.

Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence

Antibody Dilution Recommended: WB (1:1000); optimal dilutions for assays should be determined by the user.

Antibody Potency: In mouse brain lysates, this antibody detects a ~60 kDa protein by Western blotting.

Antibody Species Reactivity: Human | Rat

Antibody Positive Control: A 1:100 dilution of SMC-493 was sufficient for detection of GABA-A R, Epsilon in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Antibody Specificity: Very high

Related Product 1: GABA-A Receptor Alpha2 pan-specific antibody (Cat. No.: AB-NN250-1)

Related Product 2: GABA-A Receptor Alpha4 pan-specific antibody (Cat. No.: AB-NN251-1)

Related Product 3: GABA-A Receptor Alpha5 pan-specific antibody (Cat. No.: AB-NN252-1)

Scientific Background: The GABA-A receptor is a member of the superfamily of fast acting ligand-gated ion channels. The individual subunits of these receptors have similar sequences and structural features (1). GABA-A receptors are the major fast inhibitory neurotransmitter gated ion channels in the brain (2). Brainstem expression of GABA-A Receptor, Epsilon, is upregulated during pregnancy (3).